NeuroElectro Publications

Article: Promoter Hypermethylation Profiling Identifies Subtypes of Head and Neck Cancer with Distinct Viral, Environmental, Genetic and Survival Characteristics.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Choudhury JH; Ghosh SK
PLoS ONE, 2015

10.1371/journal.pone.0129808.t002 Table 2

Genes/loci	Frequency of methylation (%)
	Tumor tissue	Normal tissue	P-value
Tumor suppressor genes
p16
Unmethylated	48 (67.6)	39 (86.7)
Methylated	23 (32.4)	6 (13.3)	0.02
DAPK
Unmethylated	50 (70.4)	40 (88.9)
Methylated	21 (29.6)	5 (11.1)	0.02
BRCA1
Unmethylated	58 (81.7)	41 (91.1)
Methylated	13 (18.3)	4 (8.9)	0.16
GSTP1
Unmethylated	49 (69)	38 (84.4)
Methylated	22 (31)	7 (15.6)	0.06
ECAD
Unmethylated	48 (67.6)	41 (91.1)
Methylated	23 (32.4)	4 (8.9)	0.04*
RASSF1
Unmethylated	35 (49.3)	35 (77.8)
Methylated	36 (50.7)	10 (22.2)	0.02*
MLH1
Unmethylated	67 (94.4)	44 (97.8)
Methylated	4 (5.6)	1 (2.2)	0.38
Tumor-specific loci
MINT1
Unmethylated	40 (56.3)	39 (86.7)
Methylated	31 (43.7)	6 (13.3)	0.01*
MINT2
Unmethylated	34 (47.9)	40 (88.9)
Methylated	37 (52.1)	5 (11.1)	<0.01*
MINT31
Unmethylated	38 (53.5)	37 (82.2)
Methylated	33 (46.5)	8 (17.8)	0.01*

Wilcoxon rank-sum test was used to calculate P-value

*Bonferroni correction of significance was applied

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source